Genomics England

SDHB

succinate dehydrogenase complex iron sulfur subunit B

Panel	Mode of inheritance	Details
Filter panels9 panels
Green in Adult solid tumours cancer susceptibility Signed-off version 2.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes Familial Paraganglioma and Pheochromocytoma
Green in Inherited phaeochromocytoma and paraganglioma excluding NF1 R-numbers: R223 Signed-off version 3.0	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Paragangliomas 4, OMIM:115310, Pheochromocytoma, OMIM:171300, Paraganglioma and gastric stromal sarcoma, OMIM:606864
Green in Inherited predisposition to GIST R-numbers: R363 Signed-off version 1.2	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Phenotypes
Green in Inherited renal cancer R-numbers: R224 Signed-off version 1.2	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Phenotypes Cowden syndrome 2, Gastrointestinal stromal tumor, Paraganglioma and gastric stromal sarcoma, Paragangliomas 4, Pheochromocytoma.
Green in Likely inborn error of metabolism Component of the following Super Panels: - Childhood onset leukodystrophy - Hypotonic infant - Paediatric disorders - Unexplained death in infancy and sudden unexplained death in childhood R-numbers: R98 Signed-off version 6.14	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in Mitochondrial disorder with complex II deficiency R-numbers: R354 Signed-off version 2.2	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in Mitochondrial disorders Component of the following Super Panels: - Childhood onset leukodystrophy Signed-off version 7.4	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in Possible mitochondrial disorder - nuclear genes R-numbers: R63 Signed-off version 3.105	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224
Green in White matter disorders and cerebral calcification - narrow panel Component of the following Super Panels: - Childhood onset leukodystrophy Signed-off version 5.3	BIALLELIC, autosomal or pseudoautosomal	Phenotypes Mitochondrial complex II deficiency, nuclear type 4, OMIM:619224